The Baltimore region has drawn its economic health from its port and a number of large manufacturing facilities. Our port has been declining in its relative significance, and heavy manufacturing is becoming more difficult to sustain in the face of increased foreign competition. It is of critical importance for our region, as it is for our country, that we be on the cutting edge of scientific exploration and discovery. The Abell Foundation believes that our community must have a strategy for adding to our scientific infrastructure if our region is to remain competitive. Periodically, this report will highlight opportunities that we feel are deserving of community support.